构建个人数字双胞胎以优化健康和药物模拟
嗨，HN，
我们正在开发BioReplica，一个平台，让你可以基于自己的DNA、医疗记录、可穿戴设备数据和生理指标，创建一个数字化的生物复制品。
为什么要这样做？
目前，如果你想知道某种补充剂、饮食或锻炼方案对你会有什么影响，通常需要自己进行实验，并寄希望于结果的好坏。
每个人的身体反应都不尽相同，但个性化仍然主要依赖于猜测。
BioReplica是一个早期尝试，旨在改变这一现状。
我们构建一个个人生物模型，这个模拟让你可以在真实生活中尝试之前，安全地测试“如果……会怎样？”的情景。
举例来说：
“如果我开始服用NMN，我的炎症指标会改善还是恶化？”
“根据我的基础数据，间歇性禁食会影响我的心脏健康风险吗？”
“这个新的认知增强剂是否可能与我的基因或药物产生不良互动？”
你将不再仅仅获得通用建议，而是可以看到基于你自身、你的基因组、你的健康历史以及你日常生理状态的预测。
我们处于非常早期的阶段。
目前的模拟比较基础，主要集中在生活方式和补充剂的干预上。
但随着时间的推移，我们的目标是让其变得更加丰富，增加数据输入，改善建模，提高准确性。
注意事项：
生物学仍然是复杂的，模拟是基于概率的，而非确定性的。
该平台不是诊断工具，也不能替代真正的医学（也不应该这样）。
正确建模是困难的，我们对此非常坦诚。
长期目标是将这些复制品用于制药模拟。在今天的临床试验中，大多数失败发生在后期，花费数十亿，有时只有在那时我们才会了解到某种药物无效或存在隐藏风险。
尽管如此，我们相信，即使是不完美的模拟，如果使用得当，也能帮助人们做出更明智的健康决策。
如果这个想法引起了你的共鸣（或者你发现我们应该考虑的缺陷），我们非常欢迎反馈。
想了解更多，请访问 https://bioreplica.ai/landing
查看原文
Hi HN,<p>We’re working on BioReplica, a platform that lets you create a digital replica of your own biology, based on your DNA, medical records, wearable data, and physiological metrics.
Why?
Right now, if you want to know how a supplement, diet, or exercise protocol will affect you, you usually have to experiment on yourself and hope for the best.
No two bodies respond the same way, but personalization is still mostly guesswork.
BioReplica is an early attempt to change that.
We build a personal biological model, a simulation that lets you test "what if?" scenarios safely before trying them in real life.<p>Examples:<p>"If I start taking NMN, will my inflammation markers likely improve or worsen?"<p>"Would intermittent fasting affect my heart health risk, based on my baseline data?"<p>"Is this new nootropic likely to interact badly with my genetics or medications?"<p>Instead of generic advice, you can start seeing predictions based on you, your genome, your health history, your day-to-day physiology.<p>We’re very early.
Right now the simulations are basic, focused mainly on lifestyle and supplement interventions.
But over time, the idea is to make it richer, more data inputs, better modeling, higher accuracy.<p>Caveats:<p>Biology is still messy, and simulations are probabilistic, not certainties.<p>The platform isn't diagnostic or a substitute for real medicine (and shouldn’t be).<p>Getting the modeling right is hard, and we’re very upfront about that.
The long term goal is for these replica's to be used for pharma simulations. In clinical trials today, most failures happen late, billions spent, and sometimes only then do we learn that a drug doesn’t work or has hidden risks.<p>Still, we believe even imperfect simulations, if used carefully, can help people make smarter decisions about their health.<p>If this idea resonates (or if you see flaws we should be thinking about), we’d love feedback.
Learn more on https://bioreplica.ai/landing