上传23andMe、myHeritage和MyAncestry，获得1200的GRS评分和一个长寿方案。
嗨，HN。我创建了 Helix（https://helixsequencing.com）——上传您现有的 23andMe、AncestryDNA 或 MyHeritage 原始数据文件，获取全面的基因组分析。这个服务是免费的。
大约有 4000 万人拥有未被利用的 DNA 芯片数据。大多数消费者报告提供 30 到 300 种健康特征的分析。而我们则在每个主要疾病类别中提供超过 1261 种多基因风险评分，扫描超过 40 万个变异与 ClinVar 的致病发现进行比对，针对 34 个基因进行药物基因组学分析（通过 CPIC 提供 110,000 多种基因型），并生成基于 AI 的长寿方案。
评分的工作原理：
- 效应等位基因剂量 × 已发布的 PGS 目录权重
- 与来自 2504 个 1000 基因组第 3 阶段样本的经验分布进行百分位比较，涵盖 5 个祖先群体（欧洲、非洲、东亚、南亚、美洲）
- 通过岭回归进行的祖先感知机器学习校正（包括 8 个特征，包含祖先比例）
- 可选的深度插补（Beagle 5.5）将 609,000 个芯片变异扩展到约 2800 万
- 每个评分显示置信水平、变异覆盖率和人群校准
您将获得：
- 按类别组织的 1261 种以上的多基因风险评分（心血管、神经系统、代谢、癌症、自身免疫等）
- ClinVar 致病变异匹配（扫描超过 40 万个）
- 药物基因组学：34 个基因的星等位基因识别及 CPIC 剂量建议
- 收敛检测：当多个 PRS + 单基因变异指向同一疾病通路时进行标记
- AI 生成的长寿方案（补充剂、训练、饮食——全部与您的基因特征相匹配）
- 互动基因组浏览器 + 4 个可下载的 PDF（健康摘要、医生报告、完整分析、健康方案）
- JSON 导出功能，将您的基因特征提供给 AI 助手
隐私（这是主要的设计约束）：
零数据保留。没有账户、没有 cookies、没有追踪。您的 DNA 文件在分析后立即从磁盘删除（约 2 分钟）。所有剩余数据（报告、评分、PDF）将在 2 小时内清除。在删除时，您会收到自动生成的数据删除证明——一份带有 SHA-256 证明哈希的 PDF（SHA256(certificateId:jobId:deletedAt:salt)），证明您的每一份数据何时被销毁。每次删除都会记录在一个仅追加的审计日志中，且不包含任何遗传数据。我们之所以专门构建这个，是因为 23andMe 的破产暴露了 1500 万人的 DNA。这里根本没有任何可以被侵犯的东西。
诚实的警告：
- PRS 仅捕捉常见变异风险——它们不是水晶球，只显示相对于人群的相对遗传风险
- 大多数 PGS 模型是在欧洲人群中开发的；跨种族表现各异
- 这是一种研究/教育工具，而不是认证的诊断工具
- 仍然存在一些粗糙的地方——到目前为止，我们只测试了少数人
我们获得了一些出乎意料的准确结果——一份报告独立标记了与我们未提及的已知医疗状况一致的遗传变异。
我们将向前五位评论者赠送 5 个免费测试代码。真心希望能收到诚实的反馈、错误报告和批评。
请通过 hello@helixsequencing.com 与我们联系，或在 Twitter/X 上找到我们：https://x.com/HelixS96106
查看原文
Hey HN. I built Helix (https://helixsequencing.com) — upload your existing 23andMe, AncestryDNA, or MyHeritage raw data file and get a comprehensive genomic analysis. It's free.<p>~40M people have DNA chip data sitting unused. Most consumer reports give you 30-300 health traits. We score 1,261+ polygenic risk scores across every major disease category, scan 400,000+ variants against ClinVar for pathogenic findings,run pharmacogenomics on 34 genes (110K+ diplotypes via CPIC), and generate an AI-powered longevity protocol.<p><pre><code> How the scoring works:
- Effect allele dosages x published PGS Catalog weights
- Percentiled against empirical distributions from 2,504 1000 Genomes Phase 3 samples across 5 ancestry groups (EUR, AFR,EAS, SAS, AMR)
- Ancestry-aware ML correction via Ridge regression (8 features including ancestry proportions)
- Optional deep imputation (Beagle 5.5) expands 609K chip variants to ~28M
- Each score shows confidence level, variant coverage, and population calibration
What you get:
- 1,261+ polygenic risk scores organized by category (cardiovascular, neurological, metabolic, cancer, autoimmune, etc.)
- ClinVar pathogenic variant matches (400K+ scanned)
- Pharmacogenomics: star allele calling for 34 genes with CPIC dosing recommendations
- Convergence detection: flags when multiple PRS + monogenic variants point at the same disease pathway
- AI-generated longevity protocol (supplements, training, diet — all matched to your genetic profile)
- Interactive genome explorer + 4 downloadable PDFs (Health Summary, Doctor's Report, Full Analysis, Health Protocol)
- JSON export to feed your genetic profile to AI assistants
Privacy (this was the main design constraint):
Zero data retention. No accounts, no cookies, no tracking. Your DNA file is deleted from disk immediately after analysis (~2 minutes). All remaining data (reports, scores, PDFs) is purged within 2 hours. At deletion time, you receive an automated Data Deletion Certificate — a PDF with a SHA-256 attestation hash (SHA256(certificateId:jobId:deletedAt:salt)) proving when every piece of your data was destroyed. Every deletion is logged in an append-only audit trail containing zero genetic data.
We built this specifically because 23andMe's bankruptcy exposed 15 million people's DNA. There is literally nothing to breach here.
Honest caveats:
- PRS capture common variant risk only — they're not crystal balls, they show relative genetic risk vs. the population
- Most PGS models were developed in European cohorts; cross-ancestry performance varies
- This is a research/educational tool, not a certified diagnostic
- Still some rough edges — we've only tested with a handful of people so far
We've had some surprisingly accurate results — one report independently flagged genetic variants consistent with a known medical condition that hadn't been mentioned to us.
Giving away 5 free beta codes to the first commenters. Would genuinely love honest feedback, bug reports, and criticism.
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Email us at hello@helixsequencing.com or find us on Twitter/X: https://x.com/HelixS96106